The Florida Everglades are under siege. An invasion of Burmese pythons is decimating this natural wonder of the South. Entire species of animals are being wiped out. Aggressive, ravenous and incredibly fast-breeding, these pythons have no natural predator to stop them… except for man.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Man vs. Snake | 2020-03-12 | 60 min |
| Season 1 | Episode 2 | The Everglades Triangle | 2020-03-19 | 60 min |
| Season 1 | Episode 3 | Taking Back the Glades | 2020-03-26 | 60 min |
| Season 1 | Episode 4 | Rise of the Super Snakes | 2020-04-02 | 60 min |
| Season 2 | Episode 1 | Skunk Ape Alley | 2020-12-03 | 60 min |
| Season 2 | Episode 2 | Venom Warriors | 2020-12-03 | 60 min |
| Season 2 | Episode 3 | Return to the Everglades Triangle | 2020-12-10 | 60 min |
| Season 2 | Episode 4 | Gators and Ghost Towns | 2020-12-17 | 60 min |
| Season 2 | Episode 5 | Outlaw Country | 2021-01-07 | 63 min |
| Season 2 | Episode 6 | Python Gamble | 2021-01-14 | 63 min |
| Season 2 | Episode 7 | Boiling Point | 2021-01-21 | 63 min |
| Season 2 | Episode 8 | All Hands on Deck | 2021-01-28 | 63 min |
| Season 3 | Episode 1 | New Blood | 2023-01-05 | 60 min |
| Season 3 | Episode 2 | Snakes, Rattles and Rolls | 2023-01-12 | 60 min |
| Season 3 | Episode 3 | The Night Serpent | 2023-01-19 | 60 min |
| Season 3 | Episode 4 | New Hunting Grounds | 2023-01-26 | 60 min |
| Season 3 | Episode 5 | Earth Shaker | 2023-02-02 | 60 min |
| Season 3 | Episode 6 | The Snake Pit | 2023-02-09 | 60 min |
| Season 3 | Episode 7 | Up Snake Creek | 2023-02-16 | 60 min |
| Season 3 | Episode 8 | Calf Eater | 2023-02-23 | 60 min |
| Season 3 | Episode 9 | Super Snakes | 2023-03-02 | 60 min |
| Season 3 | Episode 10 | Viper Alley | 2023-03-09 | 60 min |
| Season 3 | Episode 11 | Judas Snake | 2023-03-23 | 60 min |
| Season 3 | Episode 12 | Mad Woman Woods | 2023-03-30 | 60 min |
| Season 3 | Episode 13 | The Dead Zone | 2023-04-06 | 60 min |
| Season 3 | Episode 14 | Snakin' Ain't Easy | 2023-04-13 | 60 min |
| Season 3 | Episode 15 | Dark and Dangerous | 2023-04-20 | 60 min |
| Season 3 | Episode 16 | The Final Battle | 2023-04-27 | 60 min |
| Season 4 | Episode 1 | Enemy Transformed | 2024-02-15 | 60 min |
| Season 4 | Episode 2 | Monster Highway | 2024-02-22 | 60 min |
| Season 4 | Episode 3 | Brace for Battle | 2024-02-29 | 60 min |
| Season 4 | Episode 4 | No Man's Land | 2024-03-07 | 60 min |
| Season 4 | Episode 5 | Scorched | 2024-03-14 | 60 min |
| Season 4 | Episode 6 | Path of Destruction | 2024-03-21 | 60 min |
| Season 4 | Episode 7 | Python Palace | 2024-04-04 | 60 min |
| Season 4 | Episode 8 | Blaze of Glory | 2024-04-11 | 60 min |
| Season 4 | Episode 9 | Backyard Blitz | 2024-04-18 | 60 min |
| Season 4 | Episode 10 | Full Assault | 2024-04-25 | 60 min |
| Season 4 | Episode 11 | Relentless Pursuit | 2024-05-02 | 63 min |
| Season 4 | Episode 12 | All In | 2024-05-09 | 63 min |
| Season 4 | Episode 13 | Gator Gauntlet | 2024-05-16 | 63 min |
| Season 4 | Episode 14 | Heat Is On | 2024-05-23 | 63 min |
| Season 4 | Episode 15 | Training Day | 2024-05-30 | 63 min |
| Season 4 | Episode 16 | Full Speed Ahead | 2024-05-30 | 62 min |