The Megan Mullally Show is an American talk show hosted by Megan Mullally that debuted in syndication on September 18, 2006, and was cancelled in January 2007 due to its low ratings. Early promotions for the program featured Mullally as herself and as her Will & Grace character, Karen Walker. The talk show also aired nationally on TBS and was distributed by NBC Universal Television Distribution.
Promotional television advertisements featured Mullally standing in front of the title-card attempting to correct the voice-over announcer who throughout the commercial mispronounces her name as "Minnie Minnie Moo Moo" and "Monkey McMonkey" among other names.
The first episode featured actor Will Ferrell and Jenny McCarthy.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Will Ferrell, Jenny McCarthy | 2006-09-18 | 60 min |
| Season 1 | Episode 2 | Eva Mendes, "So You Think You Can Dance", Granny Basketball | 2006-09-19 | 60 min |
| Season 1 | Episode 3 | Lisa Kudrow, 10 year-old Opera Singer, Adam Rodriguez | 2006-09-20 | 60 min |
| Season 1 | Episode 4 | Carol Burnett, Rainn Wilson, Hollerin' Championships | 2006-09-21 | 60 min |
| Season 1 | Episode 5 | Felicity Huffman, 'Animal Guys' Paul Hahn and David Riherd, Enrique Murciano | 2006-09-22 | 60 min |
| Season 1 | Episode 6 | Julia Louis-Dreyfus, Illusionist Criss Angel, Mario Lopez | 2006-09-25 | 60 min |
| Season 1 | Episode 7 | Debra Messing, Fashion Makeover with Lucky Magazine, Omar Epps | 2006-09-26 | 60 min |
| Season 1 | Episode 8 | George Lopez, Jennifer Finnigan, Vacuum Cleaning Genius, Tim Bagley At A Cher Convention | 2006-09-27 | 60 min |
| Season 1 | Episode 9 | Sela Ward, Chris Noth | 2006-09-28 | 60 min |
| Season 1 | Episode 10 | Patricia Heaton, Duane Martin, Jesse McCartney | 2006-09-29 | 60 min |
| Season 1 | Episode 11 | Jane Kaczmarek, Masi Oka, Champion Cloggers | 2006-10-02 | 60 min |
| Season 1 | Episode 12 | Tom Bergeron, Eric Stromer, Elizabeth Perkins | 2006-10-03 | 60 min |
| Season 1 | Episode 13 | Tim Daly, Domino Magazine | 2006-10-04 | 60 min |
| Season 1 | Episode 14 | Connie Britton, Michael Clark Duncan | 2006-10-05 | 60 min |
| Season 1 | Episode 15 | Jennifer Love Hewiitt, Jonny Lee Miller, J. Xavier | 2006-10-06 | 60 min |
| Season 1 | Episode 16 | Virginia Madsen, Noah Gray-Cabey, Around The Office | 2006-10-09 | 60 min |
| Season 1 | Episode 17 | Marcia Cross, Clinton Kelly, Isaiah Washington | 2006-10-10 | 60 min |
| Season 1 | Episode 18 | Molly Ringwald, OK Go | 2006-10-11 | 60 min |
| Season 1 | Episode 19 | Wanda Sykes, Goran Visnjic, Ruben Studdard | 2006-10-12 | 60 min |
| Season 1 | Episode 20 | Peter Gallagher, Nathan Burton, Tyler James Williams | 2006-10-13 | 60 min |
| Season 1 | Episode 21 | Bradley Whitford, Shelley Morrison, Eric Mabius, Mario Vazquez, Phil Pfister | 2006-10-16 | 60 min |
| Season 1 | Episode 22 | Cheyenne Kimball, Laura Linney, Ricardo Antonio Chavira | 2006-10-17 | 60 min |
| Season 1 | Episode 23 | Merv Griffin, Kim Raver, Author Jennifer Egan | 2006-10-18 | 60 min |
| Season 1 | Episode 24 | Rob Morrow, Rebecca Cole, Anne Heche, Joshua Bell | 2006-10-19 | 60 min |
| Season 1 | Episode 25 | Josh Duhamel, Alison Lohman, Authors Mark Leyner and Bill Goldberg, Aly & AJ Michalka | 2006-10-20 | 60 min |
| Season 1 | Episode 26 | Kristin Chenoweth, Jill Conner Browne, Nick & Aaron Carter, the Sweet Potato Queens | 2006-10-23 | 60 min |
| Season 1 | Episode 27 | Jamie Lee Curtis, The Mystic Pixies, Amy Smart, Taylor Swift | 2006-10-24 | 60 min |
| Season 1 | Episode 28 | Lauren Holly, Ruben Studdard, Daniel Dae Kim | 2006-10-25 | 60 min |
| Season 1 | Episode 29 | Cloris Leachman, Jensen Ackles, Dog Halloween Costumes with Teri Austin, ecostylist Danny Seo | 2006-10-26 | 60 min |
| Season 1 | Episode 30 | James Denton, Yahoo 9's Maria Sansone, Angela Kinsey, JoJo | 2006-10-27 | 60 min |
| Season 1 | Episode 31 | Steven Weber, Audra McDonald | 2006-10-30 | 60 min |
| Season 1 | Episode 32 | Neil Patrick Harris, Kevin Federline | 2006-10-31 | 60 min |
| Season 1 | Episode 33 | Jamie Kennedy, Jeffrey Sebelia, Meat Loaf, Card Thrower Rick Smith | 2006-11-01 | 60 min |
| Season 1 | Episode 34 | Clay Aiken, Tysonia Tschinga "real life" Dancing with the Stars | 2006-11-02 | 60 min |
| Season 1 | Episode 35 | Sean Hayes, Eddie Cibrian, Dog Whisperer Cesar Millan, Author Mitch Albom | 2006-11-03 | 60 min |
| Season 1 | Episode 36 | Barry Manilow, Parminder Nagra, Tim Bagley visits "America's Got Talent", Kid's Ballroom Dancing | 2006-11-06 | 60 min |
| Season 1 | Episode 37 | Mark Harmon, Hip Hop Champions, Constance Zimmer, Melora Hardin | 2006-11-07 | 60 min |
| Season 1 | Episode 38 | Kevin Nealon, Antonio Sabato Jr. | 2006-11-08 | 60 min |
| Season 1 | Episode 39 | Bob Saget, sex educator Sue Johanson | 2006-11-09 | 60 min |
| Season 1 | Episode 40 | Molly Sims, Andrea Bowen, The Ten Tenors, Celebrity trainer Michael Carson | 2006-11-10 | 60 min |
| Season 1 | Episode 41 | Cheryl Hines, Tim Gunn, Thanksgiving Dog Adoption Fashion Show | 2006-11-13 | 60 min |
| Season 1 | Episode 42 | David Hyde Pierce, Linda Cardellini, Taylor Ware | 2006-11-14 | 60 min |
| Season 1 | Episode 43 | Patricia Arquette, Champion Pirouette Dancer, Daily Candy Trends | 2006-11-15 | 60 min |
| Season 1 | Episode 44 | Dax Shepard, Tom Arnold, Kimberley Locke | 2006-11-16 | 60 min |
| Season 1 | Episode 45 | Reba McEntire, Patrick Wilson, RBD | 2006-11-17 | 60 min |
| Season 1 | Episode 46 | Tom Bergeron, Trista and Ryan, Benji Schwimmer, Rupert Boneham | 2006-11-20 | 60 min |
| Season 1 | Episode 47 | Sharon Stone, Scott Foley, Rusty Schwimmer, Paz Vega, Danny Seo | 2006-11-21 | 60 min |
| Season 1 | Episode 48 | Wayne Brady, Penguins Pete and Penny, Nestle Toll House Bake Sale Finalist | 2006-11-22 | 60 min |
| Season 1 | Episode 49 | Camryn Manheim, Phil Pfister, James Lesure, Author Karen Rizzo | 2006-11-24 | 60 min |
| Season 1 | Episode 50 | Neil Patrick Harris, Josh Radnor, Alyson Hannigan, Jason Segel and Cobie Smulders | 2006-11-27 | 60 min |
| Season 1 | Episode 51 | David Boreanaz, Julianne Nicholson, Bianca Ryan | 2006-11-28 | 60 min |
| Season 1 | Episode 52 | Matthew Broderick, Donald Faison, Brian Baumgartner, the Bucket Boys, Catherine Lloyd Burns | 2006-11-29 | 60 min |
| Season 1 | Episode 53 | Tracy Morgan, Melissa Peterman, Jarod Miller, Eric Stromer | 2006-11-30 | 60 min |
| Season 1 | Episode 54 | Carrie Fisher, Paul Rodriguez, Nadine Velazquez | 2006-12-01 | 60 min |
| Season 1 | Episode 55 | Rosanna Arquette, Tom Green, Adrian Pasdar | 2006-12-04 | 60 min |
| Season 1 | Episode 56 | Marla Sokoloff, Taylor Hicks, "Campus Ladies" | 2006-12-05 | 60 min |
| Season 1 | Episode 57 | Phyllis Diller | 2006-12-06 | 60 min |
| Season 1 | Episode 58 | Carson Kressley, Beau Bridges, Amy Sedaris | 2006-12-07 | 60 min |
| Season 1 | Episode 59 | Wendie Malick, Janice Dickinson | 2006-12-08 | 60 min |
| Season 1 | Episode 60 | John Stamos, Brenda Strong, Cris Judd, Tyrese | 2006-12-11 | 60 min |
| Season 1 | Episode 61 | David James Elliott, Michael Ealy, Lisa Edelstein, magician Nathan Burton | 2006-12-12 | 60 min |
| Season 1 | Episode 62 | Jeffrey Tambor, Tisha Campbell, designer Mark Montano, Hall & Oates | 2006-12-13 | 60 min |
| Season 1 | Episode 63 | Shawn and Marlon Wayans, Taylor Hicks | 2006-12-14 | 60 min |
| Season 1 | Episode 64 | Oded Fehr, Rob Morrow, Rhea Perlman, Sarah Rush | 2006-12-15 | 60 min |
| Season 1 | Episode 65 | Howie Mandel, Jennie Garth, Ahmet Zappa, psychic medium Lisa Williams | 2006-12-18 | 60 min |
| Season 1 | Episode 66 | Jane Seymour, David Conrad, Ken Davitian, Joshua Radin | 2006-12-19 | 60 min |
| Season 1 | Episode 67 | Alfre Woodard, Milo Ventimiglia, Fantasia Barrino | 2006-12-20 | 60 min |
| Season 1 | Episode 68 | Billy Ray Cyrus, Richard Simmons, authors of "Party Confidential" | 2006-12-21 | 60 min |
| Season 1 | Episode 69 | Hall & Oates, Brian McKnight, Clay Aiken, José Feliciano, Kimberley Locke, Celtic Woman | 2006-12-22 | 60 min |
| Season 1 | Episode 70 | Emily Procter, Tichina Arnold, Goo Goo Dolls | 2007-01-08 | 60 min |
| Season 1 | Episode 71 | Natalie Cole, Craig Bierko, Dave Annable, Blaine Zuckerman | 2007-01-09 | 60 min |
| Season 1 | Episode 72 | Tom Bergeron, Tim Daly, Will Ferrell, Allison Janney, Davy Jones, Chris Noth, Jerry Springer | 2007-01-15 | 60 min |
| Season 1 | Episode 73 | Patricia Heaton, Cheryl Hines, Debra Messing, Christine Taylor | 2007-01-16 | 60 min |
| Season 1 | Episode 74 | Josh Duhamel, Jamie Kennedy, George Lopez, Mario Lopez | 2007-01-17 | 60 min |
| Season 1 | Episode 75 | Selma Blair, Kristin Chenoweth, Lisa Kudrow, Laura Linney, Julia Louis-Dreyfus | 2007-01-18 | 60 min |
| Season 1 | Episode 76 | Chandra Wilson, Jesse Bradford, Clay Aiken | 2007-01-24 | 60 min |
