Due to a political conspiracy, an innocent man is sent to death row and his only hope is his brother, who makes it his mission to deliberately get himself sent to the same prison in order to break the both of them out, from the inside out.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Pilot | 2005-08-29 | 60 min |
| Season 1 | Episode 2 | Allen | 2005-08-29 | 60 min |
| Season 1 | Episode 3 | Cell Test | 2005-09-05 | 60 min |
| Season 1 | Episode 4 | Cute Poison | 2005-09-12 | 60 min |
| Season 1 | Episode 5 | English, Fitz or Percy | 2005-09-19 | 60 min |
| Season 1 | Episode 6 | Riots, Drills and the Devil (1) | 2005-09-26 | 60 min |
| Season 1 | Episode 7 | Riots, Drills and the Devil (2) | 2005-10-03 | 60 min |
| Season 1 | Episode 8 | The Old Head | 2005-10-24 | 60 min |
| Season 1 | Episode 9 | Tweener | 2005-10-31 | 60 min |
| Season 1 | Episode 10 | Sleight of Hand | 2005-11-07 | 60 min |
| Season 1 | Episode 11 | And Then There Were 7 | 2005-11-14 | 60 min |
| Season 1 | Episode 12 | Odd Man Out | 2005-11-21 | 60 min |
| Season 1 | Episode 13 | End of the Tunnel | 2005-11-28 | 60 min |
| Season 1 | Episode 14 | The Rat | 2006-03-20 | 60 min |
| Season 1 | Episode 15 | By the Skin and the Teeth | 2006-03-27 | 60 min |
| Season 1 | Episode 16 | Brother's Keeper | 2006-04-03 | 60 min |
| Season 1 | Episode 17 | J-Cat | 2006-04-10 | 60 min |
| Season 1 | Episode 18 | Bluff | 2006-04-17 | 60 min |
| Season 1 | Episode 19 | The Key | 2006-04-24 | 60 min |
| Season 1 | Episode 20 | Tonight | 2006-05-01 | 60 min |
| Season 1 | Episode 21 | Go | 2006-05-08 | 60 min |
| Season 1 | Episode 22 | Flight | 2006-05-15 | 60 min |
| Season 2 | Episode 1 | Manhunt | 2006-08-21 | 60 min |
| Season 2 | Episode 2 | Otis | 2006-08-28 | 60 min |
| Season 2 | Episode 3 | Scan | 2006-09-04 | 60 min |
| Season 2 | Episode 4 | First Down | 2006-09-11 | 60 min |
| Season 2 | Episode 5 | Map 1213 | 2006-09-18 | 60 min |
| Season 2 | Episode 6 | Subdivision | 2006-09-25 | 60 min |
| Season 2 | Episode 7 | Buried | 2006-10-02 | 60 min |
| Season 2 | Episode 8 | Dead Fall | 2006-10-23 | 60 min |
| Season 2 | Episode 9 | Unearthed | 2006-10-30 | 60 min |
| Season 2 | Episode 10 | Rendezvous | 2006-11-06 | 60 min |
| Season 2 | Episode 11 | Bolshoi Booze | 2006-11-13 | 60 min |
| Season 2 | Episode 12 | Disconnect | 2006-11-20 | 60 min |
| Season 2 | Episode 13 | The Killing Box | 2006-11-27 | 60 min |
| Season 2 | Episode 14 | John Doe | 2007-01-22 | 60 min |
| Season 2 | Episode 15 | The Message | 2007-01-29 | 60 min |
| Season 2 | Episode 16 | Chicago | 2007-02-05 | 60 min |
| Season 2 | Episode 17 | Bad Blood | 2007-02-19 | 60 min |
| Season 2 | Episode 18 | Wash | 2007-02-26 | 60 min |
| Season 2 | Episode 19 | Sweet Caroline | 2007-03-05 | 60 min |
| Season 2 | Episode 20 | Panama | 2007-03-19 | 60 min |
| Season 2 | Episode 21 | Fin Del Camino | 2007-03-26 | 60 min |
| Season 2 | Episode 22 | Sona | 2007-04-02 | 60 min |
| Season 3 | Episode 1 | Orientación | 2007-09-17 | 60 min |
| Season 3 | Episode 2 | Fire/Water | 2007-09-24 | 60 min |
| Season 3 | Episode 3 | Call Waiting | 2007-10-01 | 60 min |
| Season 3 | Episode 4 | Good Fences | 2007-10-08 | 60 min |
| Season 3 | Episode 5 | Interference | 2007-10-22 | 60 min |
| Season 3 | Episode 6 | Photo Finish | 2007-11-05 | 60 min |
| Season 3 | Episode 7 | Vamonos | 2007-11-05 | 60 min |
| Season 3 | Episode 8 | Bang and Burn | 2007-11-12 | 60 min |
| Season 3 | Episode 9 | Boxed In | 2008-01-14 | 60 min |
| Season 3 | Episode 10 | Dirt Nap | 2008-01-21 | 60 min |
| Season 3 | Episode 11 | Under and Out | 2008-02-04 | 60 min |
| Season 3 | Episode 12 | Hell or High Water | 2008-02-11 | 60 min |
| Season 3 | Episode 13 | The Art of the Deal | 2008-02-18 | 60 min |
| Season 4 | Episode 1 | Scylla | 2008-09-01 | 60 min |
| Season 4 | Episode 2 | Breaking and Entering | 2008-09-01 | 60 min |
| Season 4 | Episode 3 | Shut Down | 2008-09-08 | 60 min |
| Season 4 | Episode 4 | Eagles and Angels | 2008-09-15 | 60 min |
| Season 4 | Episode 5 | Safe and Sound | 2008-09-22 | 60 min |
| Season 4 | Episode 6 | Blow Out | 2008-09-29 | 60 min |
| Season 4 | Episode 7 | Five the Hard Way | 2008-10-06 | 60 min |
| Season 4 | Episode 8 | The Price | 2008-10-20 | 60 min |
| Season 4 | Episode 9 | Greatness Achieved | 2008-11-03 | 60 min |
| Season 4 | Episode 10 | The Legend | 2008-11-10 | 60 min |
| Season 4 | Episode 11 | Quiet Riot | 2008-11-17 | 60 min |
| Season 4 | Episode 12 | Selfless | 2008-11-24 | 60 min |
| Season 4 | Episode 13 | Deal or No Deal | 2008-12-01 | 60 min |
| Season 4 | Episode 14 | Just Business | 2008-12-08 | 60 min |
| Season 4 | Episode 15 | Going Under | 2008-12-15 | 60 min |
| Season 4 | Episode 16 | The Sunshine State | 2008-12-22 | 60 min |
| Season 4 | Episode 17 | The Mother Lode | 2009-04-17 | 60 min |
| Season 4 | Episode 18 | VS. | 2009-04-24 | 60 min |
| Season 4 | Episode 19 | S.O.B. | 2009-05-01 | 60 min |
| Season 4 | Episode 20 | Cowboys and Indians | 2009-05-08 | 60 min |
| Season 4 | Episode 21 | Rate of Exchange | 2009-05-15 | 60 min |
| Season 4 | Episode 22 | Killing Your Number | 2009-05-15 | 60 min |
| Season 5 | Episode 1 | Ogygia | 2017-04-04 | 60 min |
| Season 5 | Episode 2 | Kaniel Outis | 2017-04-11 | 60 min |
| Season 5 | Episode 3 | The Liar | 2017-04-18 | 60 min |
| Season 5 | Episode 4 | The Prisoner's Dilemma | 2017-04-25 | 60 min |
| Season 5 | Episode 5 | Contingency | 2017-05-02 | 60 min |
| Season 5 | Episode 6 | Phaecia | 2017-05-09 | 60 min |
| Season 5 | Episode 7 | Wine-Dark Sea | 2017-05-16 | 60 min |
| Season 5 | Episode 8 | Progeny | 2017-05-23 | 60 min |
| Season 5 | Episode 9 | Behind the Eyes | 2017-05-30 | 60 min |
| Production | Cathy Mickel Gibson | Co-Producer |
| Production | David H. Jeffery | Co-Producer |
| Production | Wentworth Miller | Producer |
| Production | Dominic Purcell | Producer |
| Production | Steve Beers | Co-Executive Producer |
| Production | Nelson McCormick | Executive Producer |
| Production | Vaun Wilmott | Executive Producer |
| Production | Michael Horowitz | Executive Producer |
| Production | Dawn Olmstead | Executive Producer |
| Production | Marty Adelstein | Executive Producer |
| Production | Neal H. Moritz | Executive Producer |
| Production | Brett Ratner | Executive Producer |
| Production | Paul T. Scheuring | Executive Producer |
