The Fran Drescher Show (2010)
- Genre: Talk
- Creator: Fran Drescher
- First Air Date: 2010-11-26
- Last Air Date: 2010-12-17
- Total Seasons: 1
- Total Episodes: 16
- Status: Ended
- Episode Runtime: 60 min.
- Production Company: Debmar-Mercury
- Network: Syndication
The Fran Drescher Show, also called The Fran Drescher Tawk Show, is a syndicated talk show hosted by actress Fran Drescher and produced by Fox Television Studios and Debmar-Mercury. The show received a three-week test run on six co-owned Fox owned and operated television stations and one CBS affiliate, WDJT/Milwaukee, which began November 26, 2010. The program is Drescher’s first foray into talk television, with Drescher and her ex-husband, Peter Marc Jacobson, serving as the executive producers.
| Production | Fran Drescher | Executive Producer |
| Production | Peter Marc Jacobson | Executive Producer |