| Season 1 | Episode 1 | Debra Messing, J.B. Smoove, Michael Ian Black, Rosie O'Donnell, Sutton Foster, Tituss Burgess | 2016-06-26 | 60 min |
| Season 1 | Episode 2 | Adam Goldberg, Ana Gasteyer, Horatio Sanz, Rosie O'Donnell, Sherri Shepherd, Tituss Burgess | 2016-07-03 | 60 min |
| Season 1 | Episode 3 | Ana Gasteyer, Bobby Moynihan, Maggie Q, Pete Wentz, Rosie O'Donnell, Tituss Burgess | 2016-07-10 | 60 min |
| Season 1 | Episode 4 | Cheryl Hines, Ike Barinholtz, Jack McBrayer, Josh Charles, Leah Remini, Leslie Jones | 2016-07-17 | 60 min |
| Season 1 | Episode 5 | David Alan Grier, Ellie Kemper, Jack McBrayer, Jason Alexander, Niecy Nash, Sheryl Crow | 2016-07-24 | 60 min |
| Season 1 | Episode 6 | Alexandra Wentworth, Kal Penn, Jack McBrayer, Niecy Nash, Mario Cantone, Cheryl Hines | 2016-07-31 | 60 min |
| Season 1 | Episode 7 | Ellie Kemper, David Alan Grier, Jack McBrayer, Jerry O'Connell, Natasha Lyonne, Niecy Nash | 2016-08-14 | 60 min |
| Season 1 | Episode 8 | Rosie O'Donnell, Sherri Shepherd, Horatio Sanz, Isaac Mizrahi, Edie Falco, D.L. Hughley | 2016-08-21 | 60 min |
| Season 1 | Episode 9 | Ellie Kemper, David Alan Grier, Jack McBrayer, Joshua Malina, Sherri Shepherd, Sheryl Crow | 2016-08-28 | 60 min |
| Season 1 | Episode 10 | Jack McBrayer, J.B. Smoove, Kristin Chenoweth, Leah Remini, Randall Park, Sarah Palin | 2016-09-19 | 60 min |
| Season 2 | Episode 1 | Jason Alexander, Cheryl Hines, Ice T, Ellie Kemper, Wayne Brady, Caroline Rhea | 2017-01-04 | 60 min |
| Season 2 | Episode 2 | Amy Sedaris, Chris D'Elia, Constance Zimmer, Jane Krakowski, Rick Fox, Tituss Burgess | 2017-01-11 | 60 min |
| Season 2 | Episode 3 | Andy Richter, Bellamy Young, Caroline Rhea, Judy Greer, Neil deGrasse Tyson, Skylar Astin | 2017-01-18 | 60 min |
| Season 2 | Episode 4 | Caroline Rhea, Chris D'Elia, Judah Friedlander, Judy Greer, Mekhi Phifer, Vivica A. Fox. | 2017-02-08 | 60 min |
| Season 2 | Episode 5 | Adam Carolla, Ana Gasteyer, Cheryl Hines, Jenna Fischer, Justin Long, Kenan Thompson | 2017-02-15 | 60 min |
| Season 2 | Episode 6 | Casey Wilson, Lamorne Morris, Leah Remini, Mario Cantone, Niecy Nash, Scott Wolf | 2017-02-22 | 60 min |
| Season 2 | Episode 7 | Tituss Burgess, Jane Krakowski, Matthew Morrison, Busy Philipps, Taye Diggs, Valerie Bertinelli | 2017-04-02 | 60 min |
| Season 2 | Episode 8 | Adam Carolla, Jenna Fischer, Tyson Beckford, Caroline Rhea, Jay Pharoah, Ana Gasteyer | 2017-04-09 | 60 min |
| Season 2 | Episode 9 | Horatio Sanz, Niecy Nash, Mario Cantone, Casey Wilson, Lamorne Morris, Martha Stewart | 2017-04-16 | 60 min |
| Season 2 | Episode 10 | Jason Alexander, Cheryl Hines, Joe Lo Truglio, Ellie Kemper, Wayne Brady, Caroline Rhea | 2017-04-23 | 60 min |
| Season 2 | Episode 11 | Adam Carolla, Ana Gasteyer, Chris Colfer, Christie Brinkley, Jay Pharoah, Wendie Malick | 2017-04-30 | 60 min |
| Season 2 | Episode 12 | Tituss Burgess, Jane Krakowski, Sasheer Zamata, Darrell Hammond, Rick Fox, Constance Zimmer | 2017-05-14 | 60 min |
| Season 3 | Episode 1 | Joel McHale, Niecy Nash, Mark Duplass, Caroline Rhea, Jason Ritter, Constance Zimmer | 2018-01-03 | 60 min |
| Season 3 | Episode 2 | Jack McBrayer, NeNe Leakes, Max Greenfield, Christina Ricci, Kenny G, Jane Krakowski | 2018-01-10 | 60 min |
| Season 3 | Episode 3 | Adam Pally, Cheryl Hines, Ron Funches, Caroline Rhea, Mario Cantone, Ana Gasteyer | 2018-01-17 | 60 min |
| Season 3 | Episode 4 | Jack McBrayer, Ellie Kemper, Anthony Anderson, Yvette Nicole Brown, James Van Der Beek, Anna Camp | 2018-01-24 | 60 min |
| Season 3 | Episode 5 | Jack McBrayer, Jane Krakowski, Rob Huebel, Ana Gasteyer, Jason Biggs, Tichina Arnold | 2018-01-31 | 60 min |
| Season 3 | Episode 6 | Lynda Carter, Sam Richardson, Cheryl Hines, Colton Haynes, Caroline Rhea, Taye Diggs | 2018-02-07 | 60 min |
| Season 3 | Episode 7 | Colin Quinn, Judy Greer, Judah Friedlander, Caroline Rhea, Orlando Jones, Abby Elliott | 2018-02-14 | 60 min |
| Season 3 | Episode 8 | Horatio Sanz, Amy Sedaris, Tim Meadows, Niecy Nash, RuPaul, Leah Remini | 2018-02-21 | 60 min |
| Season 3 | Episode 9 | Kenan Thompson, Niecy Nash, Thomas Lennon, Caroline Rhea, Mark Duplass, Constance Zimmer | 2018-06-21 | 60 min |
| Season 3 | Episode 10 | Jack McBrayer, Jenifer Lewis, James Van Der Beek, Ellie Kemper, Anthony Anderson, Kate Flannery | 2018-06-28 | 60 min |
| Season 3 | Episode 11 | Joel McHale, Constance Zimmer, David Arquette, Caroline Rhea, Michael Ealy, Laverne Cox | 2018-07-05 | 60 min |
| Season 3 | Episode 12 | Jack McBrayer, Ellie Kemper, John Early, Yvette Nicole Brown, Donald Faison, Amy Sedaris | 2018-07-12 | 60 min |
| Season 3 | Episode 13 | Mario Cantone, Cheryl Hines, Adam Pally, Caroline Rhea, Neil deGrasse Tyson, and Niecy Nash | 2018-07-19 | 60 min |
| Season 3 | Episode 14 | Jack McBrayer, Christina Ricci, Ice-T, Jane Krakowski, Tituss Burgess, Nikki Glaser | 2018-07-26 | 60 min |
| Season 3 | Episode 15 | Jason Alexander, Sheryl Underwood, Gabriel Iglesias, Constance Zimmer, Bubba Watson, Anjelah Johnson | 2018-08-09 | 60 min |
| Season 3 | Episode 16 | Kenan Thompson, Thomas Lennon, Sherri Shepherd, Horatio Sanz, Gillian Jacobs | 2018-08-16 | 60 min |
| Season 3 | Episode 17 | Mario Cantone, Sandra Bernhard, Oliver Hudson, Caroline Rhea, Adam Rodriguez, Eva Marcille | 2018-09-06 | 60 min |
| Season 3 | Episode 18 | Pamela Anderson, Ali Wentworth, Sugar Ray Leonard, Tisha Campbell-Martin, Adam Carolla, Mark Duplass | 2018-09-13 | 60 min |
| Season 4 | Episode 1 | Kenan Thompson, Ellie Kemper, Tyler Hoechlin, Sherri Shepherd, Horatio Sanz, Jillian Bell | 2019-01-09 | 60 min |
| Season 4 | Episode 2 | Joel McHale, Jane Krakowski, Finesse Mitchell, Caroline Rhea, Jason Biggs, La Toya Jackson | 2019-01-16 | 60 min |
| Season 4 | Episode 3 | Adam Carolla, Morena Baccarin, Johnny Weir, Cheryl Hines, Rick Fox, Pamela Anderson | 2019-01-23 | 60 min |
| Season 4 | Episode 4 | Chris Parnell, Whitney Cummings, Kevin Smith, Jane Krakowski, Ron Funches, Caitlyn Jenner | 2019-01-30 | 60 min |
| Season 4 | Episode 5 | Jason Alexander, Niecy Nash, Judah Friedlander, Constance Zimmer, Michael Che, Erika Christensen | 2019-02-13 | 60 min |
| Season 4 | Episode 6 | Mario Cantone, Raven-Symoné, Oliver Hudson, Caroline Rhea, Finesse Mitchell, Julie Klausner | 2019-02-20 | 60 min |
| Season 4 | Episode 7 | Jason Alexander, Sheryl Underwood, Gabriel Iglesias, Constance Zimmer, Michael Che, Bridget Everett | 2019-06-12 | 60 min |
| Season 4 | Episode 8 | Chris Parnell, Whitney Cummings, Tony Rock, Jane Krakowski, Rob Riggle, Sarah Chalke | 2019-06-19 | 60 min |
| Season 4 | Episode 9 | Joel McHale, Rachael Ray, Jason Biggs, Caroline Rhea, Donald Faison, Vanessa Williams. | 2019-06-26 | 60 min |
| Season 4 | Episode 10 | Mario Cantone, Raven Symoné, Hasan Minhaj, Caroline Rhea, Wayne Newton, Sandra Bernhard | 2019-07-17 | 60 min |
| Season 4 | Episode 11 | Chris Parnell, Kym Whitley, Rob Riggle, Caitlyn Jenner, Jay Pharoah, Sarah Chalke. | 2019-07-24 | 60 min |
| Season 4 | Episode 12 | Horatio Sanz, Sherri Shepherd, Thomas Lennon, Ellie Kemper, Kenan Thompson, Kyle Richards | 2019-07-31 | 60 min |
| Season 4 | Episode 13 | Michael Che, Kirstie Alley, Chris D'Elia, Sherri Shepherd, Mark Duplass, Brooklyn Decker | 2019-08-07 | 60 min |
| Season 4 | Episode 14 | Code Blue | 2019-08-14 | 60 min |
| Season 5 | Episode 1 | Shooting Blanks | 2020-05-31 | 60 min |
| Season 5 | Episode 2 | Sam Richardson, Jane Krakowski, Ben Schwartz, Caroline Rhea, James Van Der Beek, Vivica A Fox | 2020-06-07 | 60 min |
| Season 5 | Episode 3 | Joel McHale, Amy Sedaris, Kevin Smith, Raven-Symoné, Ne-Yo, Malin Akerman | 2020-06-14 | 60 min |
| Season 5 | Episode 4 | Thomas Lennon, Mary McCormack, Rick Fox, Caroline Rhea, Bob Saget, Padma Lakshmi | 2020-06-28 | 60 min |
| Season 5 | Episode 5 | Adam Carolla, Cheryl Hines, Nick Swisher, Ali Wentworth, Mark Duplass, Loni Love | 2020-07-12 | 60 min |
| Season 5 | Episode 6 | 58th Episode Celebration- Jerry Ferrara, Constance Zimmer, Chris Sullivan, Caroline Rhea, Ross Matthews, Dascha Polanco | 2020-09-24 | 60 min |
| Season 5 | Episode 7 | James Van Der Beek, Cheryl Hines, Thomas Lennon, Sherri Shepherd, Dr. Oz, Laura Benanti | 2020-10-01 | 60 min |
| Season 5 | Episode 8 | Joel McHale, Amanda Seales, Ron Funches, Ana Gasteyer, Rob Huebel, Nikki Glaser | 2020-10-08 | 60 min |
| Season 5 | Episode 9 | Joel McHale, Jane Krakowski, Jermaine Fowler, Caroline Rhea, Skylar Astin, Retta | 2020-10-29 | 60 min |
| Season 5 | Episode 10 | Match Gala - Mario Cantone, Vivica A Fox, Antonio Brown, Hilaria Baldwin, Fred Armisen, Christie Brinkley | 2021-07-21 | 60 min |
| Season 5 | Episode 11 | Horatio Sanz, Marilu Henner, Michael Colter, Ali Wentworth, Justin Long, Drea de Matteo | 2021-07-28 | 60 min |
