Shorts from "The New Adventures of Mighty Mouse and Heckle and Jeckle" Saturday morning cartoon show edited together into a movie. Space cat villain Harry the Heartless holds space mouse Queen Pureheart. Only Mighty Mouse can save her.
Unfortunately the movie Mighty Mouse in the Great Space Chase is not yet available on HBO Max.
| Visual Effects | Milton Gray | Animation |
| Sound | Norm Prescott | Music |
| Directing | Gwen Wetzler | Director |
| Editing | Earl Biddle | Editor |
| Production | Lou Scheimer | Producer |
| Directing | Ed Friedman | Director |
| Directing | Louis Zukor | Director |
| Directing | Marsh Lamore | Director |
| Directing | Lou Kachivas | Director |
| Directing | Kay Wright | Director |
| Editing | Jim Blodgett | Editor |
| Production | Norm Prescott | Producer |
| Editing | Ann Hagerman | Editor |
| Sound | Ray Ellis | Music |
| Crew | R.W. Pope | Cinematography |
| Production | Don Christensen | Producer |
| Writing | Sam Simon | Writer |
| Writing | Buzz Dixon | Writer |