Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.
Unfortunately the movie Drugstore Cowboy is not yet available on HBO Max.
| Writing | Gus Van Sant | Screenplay |
| Writing | Daniel Yost | Screenplay |
| Production | Richard Pagano | Casting |
| Art | Margaret Goldsmith | Set Decoration |
| Camera | Robert D. Yeoman | Director of Photography |
| Production | Sharon Bialy | Casting |
| Directing | Gus Van Sant | Director |
| Art | Eve Cauley | Art Direction |
| Art | David Brisbin | Production Design |
| Sound | Elliot Goldenthal | Original Music Composer |
| Production | Karen Murphy | Producer |
| Production | Nick Wechsler | Producer |
| Production | Cary Brokaw | Executive Producer |
| Editing | Mary Bauer | Editor |
| Directing | Jane Goldsmith | Script Supervisor |
| Costume & Make-Up | Gina Monaci | Hair Designer |
| Costume & Make-Up | Lizbeth Williamson | Makeup Artist |
| Sound | Joel Iwataki | Sound Engineer |
| Editing | Curtiss Clayton | Editor |
| Production | Laurie Parker | Production Executive |
| Production | Claudia Lewis | Production Executive |
| Sound | Jerry Trent | Foley Artist |
| Directing | Robin Leigh Fleck | Second Assistant Director |
| Camera | Les Percy | Key Grip |
| Crew | Leslie A. Leitner | Post Production Supervisor |
| Sound | Joan Rowe | Foley Artist |
| Sound | Matthew Iadarola | Sound Re-Recording Mixer |
| Production | Charles Harrington | Location Manager |
| Writing | James Fogle | Novel |
| Sound | Robert Jackson | Boom Operator |
| Sound | Dane A. Davis | Supervising Sound Editor |
| Sound | Wayne Heitman | Sound Re-Recording Mixer |
| Production | Karen Koch | Production Manager |
| Art | Missy Stewart | Set Dresser |
| Sound | Mark 'Frito' Long | Sound Recordist |
| Costume & Make-Up | Beatrix Aruna Pasztor | Costume Designer |
| Sound | John Kwiatkowski | Sound Effects Editor |
| Production | Eric McLeod | Production Coordinator |
| Crew | David Boushey | Stunt Coordinator |
| Directing | David B. Householter | First Assistant Director |
| Art | Michael Gastaldo | Property Master |
| Camera | Eric Alan Edwards | Second Unit Director of Photography |
| Sound | Ron Judkins | Sound Mixer |
| Costume & Make-Up | Marsha Perloff | Wardrobe Supervisor |
| Lighting | Chris Morley | Gaffer |
