In the not-too-distant future, the last two men on earth must adapt and evolve to save humanity.
Unfortunately the movie Biosphere is not yet available on HBO Max.
| Directing | Mel Eslyn | Director |
| Production | Zackary Drucker | Producer |
| Production | Mel Eslyn | Producer |
| Writing | Mark Duplass | Writer |
| Writing | Mel Eslyn | Writer |
| Sound | Danny Bensi | Original Music Composer |
| Sound | Saunder Jurriaans | Original Music Composer |
| Camera | Nathan M. Miller | Director of Photography |
| Art | Megan Fenton | Production Design |
| Art | Christine Brandt | Art Direction |
| Costume & Make-Up | Ronald Leamon | Costume Design |
| Production | Emily A. Neumann | Unit Production Manager |
| Directing | Drew Langer | First Assistant Director |
| Sound | Sam Donalds | Boom Operator |
| Sound | Daniel S. McCoy | Sound Mixer |
| Sound | Samya McCoy | Boom Operator |
| Sound | Nathan Van Halla | Sound Mixer |
| Costume & Make-Up | Bree Bañuelos | Set Costumer |
| Editing | Nicholas Hasson | Colorist |
| Editing | Matthew Hawkins | Dailies Technician |
| Editing | Ken Lebre | Dailies Manager |
| Crew | Alex Regalado | Post Production Supervisor |
| Sound | Jillian Ennis | Music Supervisor |
| Sound | Phil McGowan | Scoring Mixer |
| Production | Maddie Buis | Producer |
| Editing | Chris Donlon | Editor |
| Production | Mark Duplass | Executive Producer |
| Production | Jay Duplass | Executive Producer |
| Production | Shuli Harel | Producer |
| Art | Samantha Bowling | Set Decoration |
| Sound | Dave Howe | Sound Re-Recording Mixer |
| Sound | Karen Howe | Foley Artist |
| Sound | Mike McAuliffe | Sound Designer |
| Crew | Mark Fenlason | Special Effects Coordinator |
| Visual Effects | Cory Lee | Visual Effects Supervisor |
| Camera | Daniel Rios | Second Assistant "B" Camera |
| Camera | Sela Shiloni | Still Photographer |
| Camera | Jessica Perez | Still Photographer |
| Camera | William Navarro | Grip |
| Camera | James Geyer | Steadicam Operator |
| Lighting | Armando Ballesteros | Gaffer |
| Camera | Armando Ballesteros | Camera Operator |
| Directing | Josh Spiegel | Second Assistant Director |
| Production | Mel Eslyn | Executive Producer |
